Dr. Limon research in the Mitchell Center for Neurodegenerative Diseases at UTMB focuses on understanding pathophysiological processes that underlie the synaptic remodeling of excitatory and inhibitory signaling in neurological and mental disorders, with the goal to generate better pharmacological strategies to correct abnormal neurotransmission. By using a multidisciplinary approach including the electrophysiological recording of human native receptors affected by disease in Microtransplantation of Synaptic Membranes (MSM) studies, and integrating this functional information with the multiple layers of clinical, histological, transcriptomic and proteomic data from the same subjects, Dr Limon’s group is gaining novel insights of molecular processes that are most likely occurring in living human brains affected by neurological and psychiatric disorders.