Noninvasive audiovisual neurostimulation (flicker) alters neural activity and neuropathology in male rodent models in regions of the brain important for learning and memory, as well as primary sensory cortices. My current research provides insight into the potential efficacy of noninvasive audiovisual neurostimulation as a future therapeutic for neurodegenerative disease and neural dysfunction by examining changes in microglial recruitment, neurovasculature, and biomarkers important in Alzheimer’s disease (AD) neuropathology across sex. The long-term goal of my research program is to develop noninvasive strategies to reverse cognitive deficits that are disrupted in normal aging and in neurodegenerative disease.